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Patients should be counseled to use a nonoral contraceptive method or add a barrier method for 4 weeks after initiation and for 4 weeks after each dose escalation

39 Additionally, there is established evidence of alterations in glutamate circuits and GABAergic circuits in ASD patients, as manifested by increased numbers of excitatory synapses and spine densities, significantly reduced levels of glutamic acid decarboxylase, and GABAA and GABAB receptor alterations in the postmortem brains of patients with autism

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Journal of Science and Medicine in Sport, 24 (1), 9297

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DOI: 10.1056/NEJMoa2413258 [Google Scholar] Hawary OA, Wadie W, El-Said YAM, Hassan OF