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The problem with prolonged caloric deficit is that metabolic adaptation your body downregulates energy expenditure over time to resist the deficit

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Some researchers prefer an alternative method

Research suggests it promotes fat loss while preserving lean mass, which aligns well with Retatrutides metabolic profile

Studies, including those published as recently as late 2025, indicate that this mechanism can lead to a reduction in fat cell size and proliferation, alongside an increase in resting metabolic rate