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Data extraction Study characteristics were extracted by a single author and included the following parameters: target organ/tissue/cell, targeting moiety, target receptor, anchoring method of the ligand to the delivery system, type of lipid delivery system, nucleic acid cargo and experimental parameters related to biodistribution and gene expression

In vitro fertilization (IVF) (Figure 3), which involves the fertilization of a mature oocyte outside of the female body, is available to infertile couples for whom intrauterine insemination is infeasible or unsuccessful

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