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More importantly, we innovatively discovered that independent of its primary target, DNA-PKcs, KU-57788 binds to and activates DRP1, leading to excessive mitochondrial fission and activation of the NRF2/SLC7A11/GSH axis, thereby protecting ATC cells from ferroptosis

This interaction triggers the activation of rapidly accelerated fibrosarcoma (RAF) components (BRAF, ARAF, and CRAF), which are integral to the pathway [110]

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[DOI] [PMC free article] [PubMed] [Google Scholar] 20.Rajizadeh M.A., Bejeshk M.A., Doustimotlagh A.H., Najafipour H., Eftekhari M., Mahmoodi M., Azizi M., Rostamabadi F., Pourghadamyari H

Han and Gross, 2022)