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These receptors/transporters are present on the luminal membrane of the cerebrovascular endothelial cells for transport of their corresponding substrates from the peripheral blood circulation

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From 2008-2010, Sanofi-Aventis Acomplia (selective CB1 antagonist) and Abbott Laboratories Meridia (NE/5-HT reuptake inhibitor)--both also designed to suppress appetite--were pulled from the market over similar cardiac safety concerns