Given that retatrutide targets an additional receptor (glucagon) and has shown superior weight loss even to tirzepatide in cross-trial comparisons, Eli Lilly may price it at a premium
SITUATIONS WHERE SAXENDA MAKES SENSE When Saxenda May Still Be Used Despite Zepbound's superior efficacy, Saxenda remains appropriate in several situations: Pediatric Patients (Ages 12-17) Saxenda was the first GLP-1 FDA-approved for adolescents 12 and older (December 2020)
100mg (Ubiquinone) Other Ingredients: Filtered Water, Natural Vegetable Glycerin, Fructose Crystalline, Natural Flavoring and/or concentrated Juice Extracts, Citric Acid, Xanthan Gum, Potassium Sorbate (to preserve freshness), Luo-Han Guo Extract, Grapefruit Seed Extract (to preserve freshness)
Are there serious risks associated with GLP-1 medications
Current and Resolved Drug Shortages and Discontinuations Reported to FDA (US FDA, 2023)
Retatrutide is described as a GIP, GLP-1 and glucagon tri-agonist studied in incretin-pathway and glucagon-receptor research models