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Pcca -/- (A138T) mice ( FVB strain, male, 1620 weeks old) were divided into two groups: a control group (fed, n = 5) and a fasting group (fasting, n = 5), with the fasting group undergoing a 2324 h fasting period prior to the tracing experiment

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Needle phobia affects an estimated 20-30% of the adult population, and the logistics of cold-chain storage, injection site management, and weekly self-administration limit the reach of these therapies to a fraction of the eligible patient population