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Combination therapies that unify the benefits of SGLT2 inhibition with other glucose-lowering mechanisms (like GLP-1 agonism) are also in development to provide multifaceted treatment approaches

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Epub 2019 Nov 3

Although treating these cells with high concentrations of glutamine alone does increase the cellular content of glutamate (through glutaminase action), this does not stimulate insulin secretion [70]

(3) Activation of GLP-1R suppressed microglial morphological changes and inflammatory factor release in the TNC in CM mice and in vitro

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