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Primary pain in ALS includes neuropathic pain and pain due to spasticity or cramps, whereas secondary pain is mainly nociceptive and may appear as muscle weakness and atrophy progress [83]

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Coskun T, MOYERS JS, ROELL WC, et al (2021) 679-P: the novel GIP, GLP-1, and glucagon triple receptor agonist LY3437943 exhibits robust efficacy in preclinical models of obesity and diabetes

Genetic variations, diet, and age also play a role, as can taking certain medications, such as birth control pills

Importantly, IBS itself does not cause weight gain or loss inherently, but its symptoms can indirectly affect nutrition and lifestyle