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45 A similar benefit was shown in analyses by baseline KCCQ-CSS tertiles, BMI, and LVEF subgroups

These adaptor proteins become phosphorylated and activated facilitating the recruitment of Grb2/SOS (son of sevenless, the guanine nucleotide exchange factor) complex which activates Ras by promoting the exchange of GDP for GTP on this proto-oncogene, converting it to its active form

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