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H&E staining results further confirmed that the aortic wall thickness of mice treated with FOXO4-DRI was significantly thinner, and ultrasound examination results showed that the PWV of the aorta was slowed down after FOXO4-DRI treatment, indicating better vascular elasticity and significantly improved vascular function compared to the control group (Figures 2D,E)

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Early during the pandemic, cancer screening rates decreased dramatically and an estimated 35% of Americans missed routine cancer screening due to Covid-19-related fears and care disruptions when many facilities reduced or suspended services