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Additional information Supplementary Information accompanies this paper on Blood Cancer Journal website Supplementary information Rights and permissions This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License

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It carries an arginine substitution at position 3 and a 13-amino-acid N-terminal extension, giving it 83 amino acids total versus 70 for native IGF-1

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Many patients that struggle with hyperpigmentation express that it is a source of great frustration and negatively impacts their self-esteem, which can be especially true for individuals presenting with hyperpigmentation after having a laser treatment