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Outcomes The primary outcome in our network meta-analysis was MACE, defined as the composite of cardiovascular mortality, nonfatal myocardial infarction (MI), and nonfatal stroke

This muscle loss carries important consequences: reduced metabolic rate, decreased strength, and potentially accelerated weight regain once dietary restriction ends

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Histological analyses of brain and adipose tissues To assess changes in adipose tissue, the epididymal fat contents of the animals were harvested immediately following the termination of the experiments

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