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In a small-scale study of older patients with T2DM and mild cognitive impairment (n = 250), DPP4i-based glucose-lowering therapy was associated with a slower deterioration of cognitive function, mainly attentional and executive functions, compared to the sulfonylurea-based glucose-lowering therapy over a 2-year follow-up (Odds ratio: 0.88, 95% CI 0.450.99, p = 0.03) (Rizzo et al., 2014)

And so there was no studies being done

The use of PIONEER data, rather than observational real-world data, may be considered another limitation of the analysis

Evidence for a general amino acid permease