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Kamata, H

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Heres a detailed look at both: Endogenous Causes Oxidative Stress Oxidative stress results from an imbalance between antioxidants and pro-oxidants in the body

VEGF (vascular endothelial growth factor) induction was reported in certain models, without the transcriptional mechanism being fully dissected

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This GH/IGF-1 axis drives several key metabolic effects: Increased lipolysis, particularly in visceral fat Improved mitochondrial function Enhanced muscle protein synthesis Reduced hepatic fat accumulation Improved insulin signaling Crucially, tesamorelin preferentially reduces visceral fat , not subcutaneous fat