prediabetes and semaglutide in Patients With Schizophrenia, Prediabetes, Obesity 🚨 1. Semaglutide significantly improved insulin sensitivity, reduced insulin resistance, lowered fasting glucose, and promoted substantial weight loss in patients with antipsychotic 𝐒𝐭𝐚𝐠𝐢𝐧𝐠 𝐩𝐫𝐞𝐝𝐢𝐚𝐛𝐞𝐭𝐞𝐬 𝐚𝐧𝐝 𝐭𝐲𝐩𝐞 2

10.1016/j.neuint.2019.104624 58 LiuQ.CaiB.ZhuL.XinX.WangX.AnZ.et al (2020b)

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Novo CagriSema (cagrilintide + semaglutide) In REDEFINE-4 (84 weeks), CagriSema 2.4/2.4 mg delivered: 23.0% weight loss (efficacy estimand) 20.2% (treatment-regimen estimand) Missed non-inferiority vs tirzepatide Takeaway: Clinically strong, but not a category reset