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In this work, the authors observed an increase of survival of AIDS patients after the oral treatment with N-acetylcysteine (NAC) administration, a precursor of GSH [22, 23]

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Clinical reviews have shown that this transmucosal route successfully bypasses the destructive enzymes of the GI tract and the liver's first-pass metabolism, resulting in a rapid and statistically significant increase in blood GSH concentrations

comprehensive inflammation modulation via cytokine regulation and NF-B pathway effects