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FEBS Lett 427 :1520

Melanotan 2 was developed at the University of Arizona in order to find a synthetic variant of the hormone -MSH so that it can be researched and used for therapeutic purposes, as the natural hormone -MSH has a very short half-life

In addition to GSH inhibition, LCS3 is reported to inhibit the activity of thioredoxin reductase1 (TXNRD1), a critical antioxidant regulator maintaining the redox state of thioredoxin (TRX) [19](Supplementary Fig

*Statements regarding dietary supplements have not been evaluated by the FDA and are not intended to diagnose, treat, cure, or prevent any disease or health condition

Patients with mild disease are treated with topical regimens, including retinoids, benzyl peroxide, and/or antibiotics, and systemic treatments are added for patients with moderate to severe acne [1, 4]