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Compound-Level Evidence GHK-Cu A 2018 review in the International Journal of Molecular Sciences synthesized gene-expression data showing GHK-Cu modulates over 4,000 human genes (Pickart and Margolina)

These results all encourage a conclusion that LASSS treatment (at 1:8000 ratio to HGF) may enhance the c-met binding-affinity of HGF without disturbing HGF-c-Met signaling and that this enhancement occurs through a mechanism that is unrelated to prevention of HGF nitration

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[12] DSIP abundance has been observed to be lower in cerebrospinal fluid of research models of depression compared to the same controls

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Differential Diagnosis Conditions that may mimic CSVD include: Alzheimers disease Multiple sclerosis Normal pressure hydrocephalus Vasculitis Leukodystrophies Neurodegenerative movement disorders Mixed pathology is common, particularly coexistence of CSVD and Alzheimers disease