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An example of this would be your IGF1 levels increase after resistance training or exercise and that's more of like paracrine or autocrine and they have more local action

Oncogene, 35 (28), 36193625

An X, Shi X: Effects of electroconvulsive shock on neuro-immune responses: Does neuro-damage occur

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VIP exerts its effects by binding to specific G-protein coupled receptors, notably VPAC1 and VPAC2 receptors, which are present in various tissues including the brain, gastrointestinal tract, and immune system [3]