Among the 14,834 patients treated with tirzepatide, the risk of death was reduced by 42% compared to those on GLP-1 RAs
That additional 25 units carries 5 extra milligrams of active peptide, and those 5 mg produce a measurable difference in both weight loss velocity and appetite suppression
Inverse relation of body weight and weight change with mortality and morbidity in patients with type 2 diabetes and cardiovascular co-morbidity: an analysis of the PROactive study population
The reporting odds ratio (ROR) was calculated from 2 2 contingency tables as (a d)/(b c), where a represents AKI cases with the drug of interest, b non-AKI cases with the drug of interest, c AKI cases with the comparator drug, and d non-AKI cases with the comparator
However, both medications are mechanistically safe for the heart neither increases risk of serious arrhythmias or cardiac events in patients without pre-existing disease
Their shelf life profiles are fundamentally different, and understanding why helps you manage each type appropriately