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[14] [15] No formal drug interaction studies between tesamorelin and retatrutide have been published, and any assumptions about their combined safety profile remain speculative

Its concentrations vary widely in food, so it may be difficult to track consumption

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- If taking medications indicated for control of AD symptoms, on stable doses for at least 8 weeks prior to screening Exclusion criteria - Any history of bipolar affective disorder - A medical condition, other than AD, that may contribute to the individuals cognitive impairment - Stroke or transient ischemic attack in the past 12 months - Clinically significant unstable psychiatric condition in the past 6 months - Inability to swallow oral medications - Other medical conditions which the investigator deems would limit the individuals life expectancy to less than 6 months - Concurrent use of anti-depressant medication - Participation in another interventional clinical trial, or intake of another investigations drug within 4 weeks or 5 half-lives (whichever is longer) Study Estimands Primary estimand 1

doi: 10.1016/s0140-6736(63)90224-1

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