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There are several hypotheses for the second signal activation and further investigations are necessary in order to find whether is there any common component for all second signals described, for example, the release of ROS 93

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Tanshinone IIA is isolated from Salvia miltiorrhiza Bunge [Lamiaceae] as a diterpene quinone (Wang et al., 2010)

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[DOI] [PubMed] [Google Scholar] [45].Yang CM, Carlson GP