Substantial weight loss or a notable shift in blood sugar may mean your levothyroxine dose needs a tweak
Zepbound Data as Reported by Lilly The manufacturers language on the weight loss indication reads thus: Zepbound is indicated in combination with a reduced-calorie diet and increased physical activity: to reduce excess body weight and maintain weight reduction long term in adults with obesity or adults with overweight in the presence of at least one weight-related comorbid condition. At 72 weeks, patients taking Zepbound 15mg lost an average of 20.9% of their body weight
In the SURMOUNT-1 trial, published in the New England Journal of Medicine , the final results at 72 weeks showed mean weight reductions of 16% with the 5 mg dose, 21.4% with the 10 mg dose, and 22.5% with the 15 mg dose
Constipation NHS
oxidative stress, calcium, and glutamate toxicity overload may also lead to energy deficiencies, forming a vicious cycle with -synuclein accumulation
However, this is still being studied, and patients with type 1 diabetes should only use semaglutide under strict medical supervision
