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A 2023 study in the journal Diabetes, Obesity and Metabolism examined hormonal changes in men on semaglutide and found improvements in testosterone levels that were partially, but not entirely, explained by weight loss alone

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Aggregated peptide showed 58% lower intracellular accumulation after 24 hours compared to clear solutions, despite identical total peptide concentration in the culture medium

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They can help determine the cause and recommend appropriate treatment or further testing