Yes exogenous IGF-1 administration suppresses endogenous growth hormone and IGF-1 production through negative feedback inhibition at the hypothalamus and anterior pituitary
LaValle, RPh, CCN, MT pp 32-39)
Learn More Low-dose GLP-1 receptor agonist for appetite suppression and metabolic health
Lipids 2008
It targets fat metabolism without the insulin or IGF-1 effects of full growth hormone
"Sermorelin stimulates physiologic GH pulses, improving muscle recovery, connective tissue repair, and sleep quality critical elements of recovery and rehabilitation in both athletic and aging populations." Schmid et al., Neuroendocrinology Clinical Evidence Clinical studies have demonstrated that Sermorelin effectively increases GH and IGF-1, leading to improvements in lean body mass, sleep quality, and overall recovery capacity