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[DOI] [PMC free article] [PubMed] [Google Scholar] 16.Aroda VR, Rosenstock J, Terauchi Y, Altuntas Y, Lalic NM, Morales Villegas EC, et al

In the Look AHEAD study, which examined the effect of intensive lifestyle intervention in patients with obesity and type 2 diabetes, the composite endpoint of adverse cardiovascular events and mortality was reduced by approximately 20% over a median follow-up period of 10.2 years, only in the group of patients that achieved a weight loss of 10% or more from their initial body weight (about 40% of the intervention arm) [7, 8]

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Additionally, there is no evidence that hyperthyroidism reduces the effectiveness of semaglutide or other GLP-1 receptor agonists for their intended uses, Dr

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