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Differential catalytic efficiency of allelic variants of human glutathione S -transferase Pi in catalyzing the glutathione conjugation of thiotepa

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Clin Cancer Res 17:64376447 Lyon RP, Bovee TD, Doronina SO, Burke PJ, Hunter JH, Neff-LaFord HD, Jonas M, Anderson ME, Setter JR, Senter PD (2015) Reducing hydrophobicity of homogeneous antibody-drug conjugates improves pharmacokinetics and therapeutic index