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Loss-of-function pathogenic variants in TGFBR1 have been identified in 18 of 22 affected families.[76] Gain-of-function variants in TGFBR1 are associated with unrelated Marfan-like syndromes, such as Loeys-Dietz syndrome, which have no described increase in skin cancer risk

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RAVE GLP-1 Metabolic Energy is a promising option that supports similar pathways to help manage appetite, energy, and metabolic wellness

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