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Degeneration of these cells as a result of free radical activity results in a reduction in levels of the neurotransmitter dopamine and upsets the balance between dopamine and another brain chemical, acetylcholine
Pandey MM, Rastogi S, Rawat AKS
Similarly, in a screen of mutant KRAS lung adenocarcinoma cells, HG106 was found to specifically inhibit SLC7A11 function and decrease tumor burden in vivo via ROS induction and mitochondrial and endoplasmic reticulum dysfunction (78)
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Effect of thiol modification on brain mitochondrial complex I activity
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