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Eating a small protein-containing meal 3060 minutes before injection blunts gastric irritation without reducing peptide absorption subcutaneous administration bypasses first-pass metabolism, so food does not interfere with bioavailability

This is the first time the GIP/GLP-1 advantage over GLP-1 alone has been proven in a direct comparison, and it is why I treat "tirzepatide beats semaglutide" as a settled question rather than an open debate

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