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These can include: Digestive issues that could lead to dehydration and cause kidney damage Gastrointestinal issues like pancreatitis or gallbladder disease Low blood pressure Low blood sugar levels There is also a black box warning, the most serious kind from the FDA, on both medications for the risk of a certain rare type of thyroid cancer
specifically, semaglutide is a GLP-1 receptor agonist with 94% sequence homology to human GLP-1
Both, semaglutide and liraglutide, by binding to GLP-1R, can activate cAMP and PKA signaling cascades
Canadian patients, on the other hand, already have access to approved generics as of spring 2026
The STEP 5 extension study showed sustained weight reduction at 104 weeks even in subgroups with dose modifications [14]