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MOTS-c works further downstream by improving glucose uptake into skeletal muscle independent of insulin spikes
Investigations focus on molecular signaling interactions rather than physiological outcomes
Drug Discov Today 12(56):218224
GLP-1 prevents neurodegeneration via upregulation of GLUT, thus reducing the potential for glutamate excitotoxicity
Also, PPAR and NO are involved in the proliferation of VSMCs, and BBR was found to upregulate the PPAR-NO signaling pathway and increase vascular NO production, thereby inhibiting the proliferation of Ang IV-stimulated VSMCs (Qiu et al., 2017)
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