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Acronyms: ADT: androgen-deprivation therapy

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One of the most popular derivatives is tetrahexyldecyl ascorbate (often called THD-ascorbate), which is marketed as a more tolerable alternative that offers similar results

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Following granule exocytosis, perforin facilitates the delivery of granzymes into the cytosol of the target cell where they cleave numerous substrates, including caspases, resulting in the rapid induction of apoptosis 7,8