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Hence, cobalamin-related remethylation disorders are usually treated by intramuscular (IM) injections at an individually titrated, minimum effective dose

Thyroid 2017;27:110917.ArticlePubMed 11

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In epileptogenesis, it is known that activated astrocytes undergo molecular alterations that can contribute to neuronal hyperexcitability, such as the downregulation of gap junction connexins, glutamate transporters, and potassium channels (Devinsky et al., 2018)