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Most common side effects were mild to moderate digestive issues, more frequent at higher doses

Initially explored in diabetes and endocrinology research models , GLP-1 has since become a focus of investigation in adipose signaling, longevity pathways, and multi-organ cellular protection studies

The dosing schedule for the first 4 weeks is typically a 0.25 mg weekly dose

Patients were mostly white (68.2% and 86.4% in the setmelanotide and placebo arms, respectively), with mean ages of 18.5 years (standard deviation [SD] = 9.7 years) and 21.5 years (SD = 12.6 years), respectively

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Mitophagy and age-related pathologies: development of new therapeutics by targeting mitochondrial turnover