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Once glycogen stores are substantially depleted, the body transitions more fully towards fat metabolism (lipolysis), where stored triglycerides are broken down into fatty acids and glycerol for energy

In contrast, a Scandinavian cohort study using nationwide cancer registries found no association between GLP-1RA use and thyroid cancer (HR 0.93, 95 % CI 0.661.31) (80)

As you can imagine, a patient with this gain-of-function mutation will have elevated blood glucose, potentially leading to type II diabetes mellitus