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Aged female mice received a high-fat diet combined with angiotensin II administration, producing a phenotype that recapitulated human cardiometabolic HFpEF: obesity, glucose intolerance, inflammation, cardiac hypertrophy, fibrosis, atrial enlargement, and lung congestion

A 25 l of mouse plasma was transferred into 1.5 ml centrifuge tube which was spiked with 2.5 l of internal standard (IS) working standard solution (100 g/ml) to get final IS contraction of 250 ng/ml and the solution was vortexed

For people with diabetes, areas like the feet, ankles, and shins might take longer to heal or be more likely to get infected

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You have to take care of yourself

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