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Preclinical Evidence for Serotonergic Changes Animal studies published in Neuropharmacology (2005) demonstrated that isotretinoin administration in mice significantly reduced serotonin transporter (SERT) binding in the frontal cortex and hippocampus, suggesting altered serotonin reuptake dynamics at clinically relevant doses

Pournajaf S, Dargahi L, Javan M, Pourgholami MH

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doi: 10.1080/15216540211468

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