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The recent approval of empagliflozin for children and adolescents with T2D marks a crucial step forward, with initial studies reporting promising results

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Notably, the primary ligand for RXR is retinoic acid, which is routinely included in SC-islet differentiation protocols 4,54

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Patients should be advised that they may not have glycemic improvement for 24 weeks after initiating treatment with long-acting GLP-1 receptor agonists