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proliferation peaks on cycle days 810 and coincides with the highest concentration of estrogen receptors in the endometrium ( Endometrial growth is also promoted by an increase in insulin-like growth factors (IGF) and epidermal growth factors (EGF), both of which are stimulated by rising estradiol levels during the proliferative phase (Hofmann et al., 1991

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Studies have shown that the PI3K/Akt signaling pathway plays an important role in multiple mechanisms of RA development, including angiogenesis, the proliferation, apoptosis and metastasis of FLS, and the expression of MMPs (43, 117, 153, 173), and it can also be considered as a potential target for the treatment of RA

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