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Description

The composition is fixed across vials, which is part of what makes it useful as a standardized research tool: every reconstituted dose delivers the same ratio of components

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During oxygenated or oxygen-deprived states, hypoxia-inducible factor 1 (HIF-1) promotes Th17 differentiation by directly transcriptionally activating RORt and facilitating the formation of a tertiary complex comprising RORt, p300, and HIF-1 at the IL-17 promoter region [41]

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