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Studies involving acoustic and chemical insults show that growth factors represent a compelling class of otoprotective compounds (Yagi et al., The HGF mimetic Dihexa is a synthetically derived Angiotensin IV analog that is blood-brain barrier permeable, stable, and orally bioavailable (McCoy et al., in vitro and in vivo , making a strong case for a small molecule activator of HGF/c-Met to confer a neuroprotective benefit (Zhang et al., The experimental value of zebrafish as an animal model for in vivo drug discovery has grown rapidly due to their ease of assessment, large clutch size, and ability to recapitulate human disease conditions (MacRae and Peterson, in vivo , demonstrating that otoprotective drug discovery in zebrafish translates to mammalian systems (Owens et al., In this study, we demonstrate that Dihexa protects lateral line hair cells from aminoglycoside ototoxicity

Additionally, lack of treatment for other precipitating factors involved in the development of HE, such as oxidative stress, inflammation or other cerebral alterations, is a major limiting step in the treatment area

The average daily dosage ranges from 200 to 300 mcg

374,452,453 Additionally, EGFR inhibition in a NAFLD-associated steatosis model similarly results in reduced expression of core lipid metabolism enzymes, potentially regulated by the transcription factors ChREBP, SREBF1, PPAR, and HNF4

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