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Concurrently, LPS significantly elevated TNF- and IL-6 levels in BALF, which were markedly decreased in mice pretreated with 10 g/g GHK-Cu

Similarly, chondrocytes from aged individuals exhibited increased ROS burden and mitochondrial and genomic DNA damage 90,91,92

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Because the two pathways are mechanistically distinct, they have been studied in combination as a means of probing parallel and potentially additive signaling at the metabolic-regulatory axis

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