glp-1 muscle mass loss GDF8 and activin A blockade protects against GLP-1–induced while enhancing fat loss in obese male mice and non-human primates The GLP-1 Muscle-Loss Debate Is

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[PubMed: 23510966] (Review of the literature of case series of suspected HDS related liver injury found evidence of other explanations for the liver injury in 19 of 23 publications involving 278 of 573 patients [49%] and that these other diagnoses weakened the causality assessment in most instances)

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Phase 3 = 41% Oral GLP-1 programs (Total 63): Phase 1 = 46%

Vilsbll T, et al