NNMT is overexpressed in adipose tissue and various cancer cell lines, and its inhibition has been studied as a strategy to increase intracellular NAD+ levels, enhance one-carbon metabolism, and reduce adipogenesis in preclinical models
Clinical Trial Dosage Findings: What the Human Data Shows The Phase II clinical trials tested doses from 1 mg/day up to 10 mg/day
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THE NAD+ METABOLIC ECOSYSTEM AND NNMT'S CENTRAL ROLE NAD+ functions as a critical coenzyme in hundreds of cellular reactions: energy production (glycolysis, oxidative phosphorylation), DNA repair, circadian rhythm regulation, and stress resistance
