Pharmacological inhibition of TMA lyase by 3,3-dimethyl-1-butanol (DMB) in imiquimod-induced lupus models demonstrates multi-organ protection through TMAO suppression, including endothelial function restoration and macrophage foam cell formation inhibition independent of cholesterol modulation ( Complementary studies reveal diverse TMAO modulation strategies: Puerarin exerts atheroprotection via Prevotella copri depletion and TMA precursor reduction, while berberines vitamin-mimetic metabolite dihydroberberine disrupts gut microbial TMA biosynthesis (165, 166)
Medication interactions may also play a role
Amor NB, Jimnez A, Megdiche W, Lundqvist M, Sevilla F, Abdelly C
Safety depends on the compound, dose, route, and product purity
Here, we established that LCAD-KO mice also exhibit multiple signs of muscle dysfunction, such as significantly reduced basal locomotion, reduced grip strength, and reduced latency to fall on the hanging wire test (Supplemental Figure 1
Am J Chin Med 29, 331341, 10.1142/S0192415X01000356 (2001)