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10.3389/fimmu.2016.00532 59 LinN.ZhangY

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( A ) Representative scatter plots (left panel) of the osmotic fragility test determined by flow cytometry and percentage of RBC lysis (right panel) at 192 mOsm of RBCs from WT and 4.2 / mice treated with either vehicle or mitapivat (100 mg/kg/d) for 6 months

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Together these results suggested that the FIXgla-Fas/HEK293 reporter cell line was susceptible to VKD carboxylation, and that disruption of the enzymes associated with the vitamin K cycle would prevent apoptosis i.e., allow functional screening for any unknown enzymes associated with the vitamin K cycle via a positive selection mechanism 17

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CrAT belongs to the family of carnitine acyltransferases, which ensures the transfer of different chain acyl groups to carnitine (Fig

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