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However, their direct effects on the progression of Alzheimers disease have not been established ( Estrogens can also be synthesized de novo in the brain by neurons and astrocytes, starting from cholesterol ( 5 Estrogen effects on mitochondrial function It is also important to consider the impact of estrogens on mitochondrial function

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While anatomic narrowing of the upper airway is a critical factor, most patients also exhibit abnormalities in nonanatomic traits, such as pharyngeal muscle responsiveness, central neurohormonal control of breathing, and an awakening response [10]