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This does not always mean GLP-1 therapy is impossible

A review of 47 randomised controlled trials involving over 23,000 patients found that the greatest weight-loss effect from GLP-1 drugs was shown in participants who were young, female and not diagnosed with diabetes (so they therefore had better insulin sensitivity)

This damages red cell membranes via lipid peroxidation

10.1007/s11101-007-9079-8 Phytochem

Bioengineering (Basel) 11 , 451 (2024)

The activation of estrogen receptor leads to increased expression of cyclins, and prompts cancer cells to transition from the quiescent phase to the proliferative phase 31 , leading to tumor growth and development